Kanser Ara\u015ft\u0131rmalar\u0131nda Yeni Ufuklar: City of Hope\u2019un Yapay Zeka, Multiomik ve \u0130mm\u00fcnoterapi Alan\u0131ndaki Katk\u0131lar\u0131<\/p>\n
Kanser tedavisinde s\u0131n\u0131rlar\u0131 zorlayan geli\u015fmeler, City of Hope\u2019un \u00f6nc\u00fcl\u00fc\u011f\u00fcnde 2025 y\u0131l\u0131nda Chicago\u2019da d\u00fczenlenecek AACR Y\u0131ll\u0131k Toplant\u0131s\u0131\u2019nda kapsaml\u0131 \u015fekilde sergilenecek. Nisan ay\u0131 sonlar\u0131nda ba\u015flayan bu prestijli konferansta, City of Hope uzmanlar\u0131 74\u2019ten fazla oturumda ba\u015fkanl\u0131k yaparak kanser biliminin ileri teknolojiler ve translasyonel ara\u015ft\u0131rmalarla nas\u0131l ilerledi\u011fine dair \u00f6nemli bilgiler sunacak. ABD Sa\u011fl\u0131k Haberleri\u2019nin \u00fcst s\u0131ralar\u0131nda yer alan bu ulusal t\u0131p merkezi; temel bilim, klinik yenilikler ve toplum kat\u0131l\u0131m\u0131n\u0131 bir arada i\u00e7eren zengin bir i\u00e7erik vaat ediyor.<\/p>\n
City of Hope bilim insanlar\u0131n\u0131n ana temalar\u0131ndan biri, yapay zeka (YZ) ve multiomik verilerin kullan\u0131m\u0131yla t\u00fcm\u00f6r biyolojisinin derinlemesine analiz edilmesi. Entegratif translasyon bilimler oturumlar\u0131nda s\u00f6z sahibi olan Profes\u00f6r David W. Craig, \u201cPredictive Oncology\u201d adl\u0131 plenaryumun ba\u015fkanl\u0131\u011f\u0131n\u0131 \u00fcstleniyor. Bu oturumda, genomik, proteomik ve mekansal veriler gibi \u00e7ok katmanl\u0131 t\u00fcm\u00f6r bilgisi kullan\u0131larak hassas onkoloji alan\u0131nda yeni stratejiler tart\u0131\u015f\u0131lacak. Dr. Craig\u2019in \u00e7al\u0131\u015fmalar\u0131, t\u00fcm\u00f6r heterojenitesinin ve tedaviye diren\u00e7 mekanizmalar\u0131n\u0131n anla\u015f\u0131lmas\u0131na odaklanarak etkili kanser terapileri \u00f6n\u00fcndeki \u00f6nemli engelleri a\u015fmay\u0131 hedefliyor.<\/p>\n
Dr. Craig ayr\u0131ca e\u011fitim oturumlar\u0131nda YZ ve veri bilimi alan\u0131ndaki geli\u015fmeleri aktar\u0131yor. Tek h\u00fccreli genomik ve mekansal transkriptomik gibi y\u00f6ntemlerin kullan\u0131m\u0131yla, kanser h\u00fccrelerinin mekansal d\u00fczeni ve alt klonal \u00e7e\u015fitlili\u011fi \u00e7\u00f6z\u00fcl\u00fcyor. Bu, t\u00fcm\u00f6rlerin ilerleyi\u015fi ve tedaviye yan\u0131t mekanizmalar\u0131n\u0131 anlamada kritik rol oynuyor. Ara\u015ft\u0131rma grubu \u00f6\u011frencisi Nina Song, dijital patoloji ile genomik verilerin YZ tabanl\u0131 entegrasyonunu sunarken, agresif kanser t\u00fcrleri olan glioblastom, \u00fc\u00e7l\u00fc negatif meme kanseri ve kolorektal kanserin biyolojisi \u00fczerine yeni bulgular payla\u015f\u0131yor.<\/p>\n
\u0130mm\u00fcnoloji alan\u0131nda City of Hope, do\u011fal \u00f6ld\u00fcr\u00fcc\u00fc (NK) h\u00fccrelerin kanserle m\u00fccadeledeki \u00f6nemine odaklan\u0131yor. Eski ba\u015fkan ve NK h\u00fccre biyolojisi uzman\u0131 Michael A. Caligiuri, bu ba\u011flamda kritik e\u011fitim oturumlar\u0131na ba\u015fkanl\u0131k ediyor. NK h\u00fccreleri, \u00f6nceden tan\u0131ml\u0131 antijenlere ihtiya\u00e7 duymadan anormal h\u00fccreleri tan\u0131y\u0131p yok edebilme kabiliyetleriyle ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin \u00f6nemli akt\u00f6rleri olarak dikkat \u00e7ekiyor. Dr. Caligiuri, molek\u00fcler mekanizmalar ve NK h\u00fccre tabanl\u0131 imm\u00fcnoterapi stratejilerini anlatarak, bu h\u00fccrelerin kanser tedavisindeki potansiyelini ortaya koyuyor.<\/p>\n
Kanser tedavisinde sa\u011fl\u0131k e\u015fitsizliklerinin azalt\u0131lmas\u0131 ad\u0131na City of Hope \u00f6nemli ara\u015ft\u0131rmalar yap\u0131yor. \u00d6zellikle etnik ve sosyoekonomik farkl\u0131l\u0131klar\u0131n molek\u00fcler d\u00fczeyde incelenmesi b\u00fcy\u00fck \u00f6nem ta\u015f\u0131yor. Bu kapsamda postdoktora bilim insan\u0131 Francisco Carranza, erken ya\u015fta ortaya \u00e7\u0131kan kolorektal kanserde MYC onkogen ve WNT sinyal yolaklar\u0131ndaki de\u011fi\u015fiklikleri Hispanik\/Latino pop\u00fclasyonlar\u0131nda multiomik yakla\u015f\u0131mlarla ara\u015ft\u0131r\u0131yor. Genomik ve mekansal transkriptomik verileri birle\u015ftirerek, etniklerin kanserdeki farkl\u0131 molek\u00fcler yap\u0131s\u0131n\u0131 ortaya koyuyor ve ki\u015fiye \u00f6zel tan\u0131 ile tedavi geli\u015ftirilmesine katk\u0131da bulunuyor.<\/p>\n
Son teknoloji yapay zeka uygulamalar\u0131ndan biri olarak, Yard\u0131mc\u0131 Do\u00e7ent Enrique Velazquez Villarreal \u00f6nderli\u011finde geli\u015ftirilen PM-AI Agent, klinik onkogenomi alan\u0131nda yenilik\u00e7i \u00e7\u00f6z\u00fcmler sunuyor. Bu ak\u0131ll\u0131 sohbet sistemi, klinik, genomik ve sosyal sa\u011fl\u0131k belirleyicilerini entegre ederek, hasta grubu bazl\u0131 farkl\u0131l\u0131klar\u0131 dikkate al\u0131yor. Klinik kararlar\u0131 desteklemeyi hedefleyen bu teknoloji, sa\u011fl\u0131k hizmetlerinde adaletin sa\u011flanmas\u0131na ve karma\u015f\u0131k kanser vakalar\u0131nda daha etkin tedavilerin geli\u015ftirilmesine \u00f6nc\u00fcl\u00fck ediyor.<\/p>\n
Klinik ara\u015ft\u0131rmalar da City of Hope\u2019un \u00f6ne \u00e7\u0131kan alanlar\u0131 aras\u0131nda yer al\u0131yor. Kad\u0131n Kanserleri Program\u0131\u2019n\u0131n yeni direkt\u00f6r\u00fc Dr. Hope Rugo, antikor-ilac\u0131 konj\u00fcgatlar\u0131 (ADC\u2019ler) gibi yenilik\u00e7i tedavi y\u00f6ntemlerinde toksisite y\u00f6netimi konusuna odaklan\u0131yor. Hedefe \u00f6zg\u00fc antikorlarla g\u00fc\u00e7l\u00fc sitotoksinlerin birle\u015fti\u011fi bu terapilerde yan etkilerin azalt\u0131lmas\u0131, tedavi etkinli\u011finin art\u0131r\u0131lmas\u0131 a\u00e7\u0131s\u0131ndan kritik bir \u00e7al\u0131\u015fma alan\u0131. Dr. Rugo ayr\u0131ca biyolojik ajanlar ve T h\u00fccresi arac\u0131l\u0131 imm\u00fcnoterapiler \u00fczerine de g\u00fcncel geli\u015fmeleri payla\u015f\u0131yor.<\/p>\n
Nasofaringeal karsinomun tekrar eden veya metastatik formlar\u0131nda umut veren sonu\u00e7lar\u0131yla Dr. Aditya Shreenivas, Penpulimab adl\u0131 humanize anti-PD-1 monoklonal antikoru \u00fczerine y\u00fcr\u00fct\u00fclen Faz 3 klinik \u00e7al\u0131\u015fman\u0131n verilerini sunacak. Bu tedavi se\u00e7ene\u011fi hastalar\u0131n ya\u015fam s\u00fcresini art\u0131rmakta ve tedaviye ba\u011fl\u0131 yan etkileri azaltmakta potansiyel ta\u015f\u0131rken, City of Hope\u2019un global onkolojiye verdi\u011fi \u00f6nemi de yans\u0131t\u0131yor.<\/p>\n
Temel biyolojiden terap\u00f6tik diren\u00e7 mekanizmalar\u0131na kadar geni\u015f bir yelpazede yap\u0131lan \u00e7al\u0131\u015fmalar da konferansta yer alacak. Postdoktora ara\u015ft\u0131rmac\u0131s\u0131 Kimya Karimi, \u00f6strojen resept\u00f6r pozitif (ER+) meme kanserinde h\u00fccre d\u00f6ng\u00fcs\u00fc inhibit\u00f6rlerine kar\u015f\u0131 geli\u015fen direnci epigenetik ve molek\u00fcler d\u00fczeyde analiz ederek endokrinoterapi etkinli\u011finin geri kazan\u0131lmas\u0131n\u0131 ama\u00e7l\u0131yor. Bu \u00e7al\u0131\u015fma, meme kanserinde s\u0131kl\u0131kla kar\u015f\u0131la\u015f\u0131lan direnci a\u015fmada \u00f6nemli ipu\u00e7lar\u0131 bar\u0131nd\u0131r\u0131yor.<\/p>\n
Toplum kat\u0131l\u0131m\u0131 ve sa\u011fl\u0131k politikalar\u0131 a\u00e7\u0131s\u0131ndan da City of Hope \u00f6nemli bir rol \u00fcstleniyor. Kimlin Tam Ashing doktoras\u0131 kapsam\u0131nda, adil kanser bak\u0131m\u0131 i\u00e7in toplum ittifaklar\u0131 ve ortakl\u0131k geli\u015ftirme modellerini detayland\u0131r\u0131yor. Bu sosyal bilimlerle biyomedikal ara\u015ft\u0131rmalar\u0131n entegrasyonunu sa\u011flayan yakla\u015f\u0131mlar, kanser tedavisi alan\u0131ndaki bilimsel ilerlemelerin toplum yarar\u0131na d\u00f6n\u00fc\u015fmesini h\u0131zland\u0131r\u0131yor.<\/p>\n
Poster sunumlar\u0131nda da \u00e7e\u015fitli kanser tipleri \u00fczerinde derinlemesine analizler yap\u0131lacak. K\u0131demli ara\u015ft\u0131rmac\u0131 Jing Qian, y\u00fcksek dereceli ser\u00f6z over kanseri hastalar\u0131n\u0131n t\u00fcm\u00f6r ve ba\u011f\u0131\u015f\u0131kl\u0131k mikro\u00e7evresindeki farkl\u0131l\u0131klar\u0131 mekansal transkriptomik verilerle ortaya koyuyor. Bu bulgular, ba\u011f\u0131\u015f\u0131kl\u0131k kontrol noktas\u0131 blokaj tedavilerine yan\u0131t\u0131n ki\u015fiden ki\u015fiye de\u011fi\u015fimini a\u00e7\u0131klamada yard\u0131mc\u0131 oluyor. Benzer \u015fekilde hematoloji uzman\u0131 Peter Zang, metastatik prostat kanserinde etnik farkl\u0131l\u0131klar\u0131n spatial proteomik analizi ile biyobelirte\u00e7 geli\u015fimine \u0131\u015f\u0131k tutuyor.<\/p>\n
Son olarak, postdoktora ara\u015ft\u0131rmac\u0131s\u0131 Sydney Grant ve Yard\u0131mc\u0131 Do\u00e7ent Aritro Nath, varyasyonlu otoenkoder temelli \u00e7ok modlu veri entegrasyonu kullanarak meme kanserindeki n\u00fcks s\u00fcresi tahminini ileri seviyeye ta\u015f\u0131yor. Bu yapay zeka tabanl\u0131 prognostik model, hastalar\u0131n bireyselle\u015ftirilmi\u015f risk de\u011ferlendirmesi ve tedavi planlamas\u0131nda yeni standartlar olu\u015fturabilir.<\/p>\n
City of Hope\u2019un AACR 2025\u2019teki g\u00fc\u00e7l\u00fc temsilcili\u011fi; yapay zeka, multiomik teknolojileri ve imm\u00fcnoterapi ara\u015ft\u0131rmalar\u0131yla kanser bak\u0131m\u0131nda gelece\u011fin \u015fekillendi\u011finin en somut kan\u0131tlar\u0131ndan biri. Klinik denemelerden topluma uzanan \u00e7ok y\u00f6nl\u00fc yakla\u015f\u0131mlar, umutlar\u0131 ger\u00e7ek tedavilere d\u00f6n\u00fc\u015ft\u00fcrme \u00e7abalar\u0131n\u0131n merkezinde yer al\u0131yor.<\/p>\n
**Ara\u015ft\u0131rma Konusu**:
\nAdvances in cancer research and treatment integrating artificial intelligence, multiomics, and immunotherapy at City of Hope. <\/p>\n
**Makale Ba\u015fl\u0131\u011f\u0131**:
\nAACR 2025\u2019te City of Hope\u2019un Yapay Zeka ve Multiomik Entegrasyonu ile Kanser Ara\u015ft\u0131rmalar\u0131 <\/p>\n
**Web References**:
\nCity of Hope
\nAACR Abstracts Portal <\/p>\n
**Resim Credits**:
\nCity of Hope <\/p>\n
**Anahtar Kelimeler**:
\nAACR Annual Meeting 2025, immunotherapy advancements, precision medicine breakthroughs, City of Hope cancer research, community engagement in cancer science, artificial intelligence in oncology, multiomics cancer treatment, overcoming treatment resistance, predictive oncology strategies, translational cancer research, tumor biology exploration, tumor heterogeneity analysis<\/p>\n","protected":false},"excerpt":{"rendered":"
Kanser Ara\u015ft\u0131rmalar\u0131nda Yeni Ufuklar: City of Hope\u2019un Yapay Zeka, Multiomik ve \u0130mm\u00fcnoterapi Alan\u0131ndaki Katk\u0131lar\u0131 Kanser tedavisinde s\u0131n\u0131rlar\u0131 zorlayan geli\u015fmeler, City of Hope\u2019un \u00f6nc\u00fcl\u00fc\u011f\u00fcnde 2025 y\u0131l\u0131nda Chicago\u2019da d\u00fczenlenecek AACR Y\u0131ll\u0131k Toplant\u0131s\u0131\u2019nda kapsaml\u0131 \u015fekilde sergilenecek. Nisan ay\u0131 sonlar\u0131nda ba\u015flayan bu prestijli konferansta, City of Hope uzmanlar\u0131 74\u2019ten fazla oturumda ba\u015fkanl\u0131k yaparak kanser biliminin ileri teknolojiler ve translasyonel…<\/p>\n","protected":false},"author":1,"featured_media":3015,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_yoast_wpseo_title":"","_yoast_wpseo_metadesc":"","_yoast_wpseo_focuskw":"","rank_math_title":"","rank_math_description":"","rank_math_focus_keyword":"","_wpan_schema_json_ld":"","_wpan_ai_seo_metadata":"","_wpan_ai_seo_status":"","_wpan_ai_seo_policy":"","_wpan_ai_seo_faq_block":"","_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[28],"tags":[1112,1108,1110,1111,1109],"tmauthors":[],"class_list":{"0":"post-3014","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-kanser","8":"tag-aacr-2025-kanser-inovasyonlari","9":"tag-city-of-hope-kanser-arastirmalari","10":"tag-multiomik-veriler-ve-tumor-biyolojisi","11":"tag-nk-hucre-tabanli-immunoterapi-stratejileri","12":"tag-yapay-zeka-ile-kanser-tedavisi"},"jetpack_featured_media_url":"https:\/\/haber360.com\/wp-content\/uploads\/2025\/04\/City-of-Hope-AACR-20258217te-Inovasyonlari-Tanitacak-1744915458.jpg","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/posts\/3014","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/comments?post=3014"}],"version-history":[{"count":0,"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/posts\/3014\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/media\/3015"}],"wp:attachment":[{"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/media?parent=3014"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/categories?post=3014"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/tags?post=3014"},{"taxonomy":"tmauthors","embeddable":true,"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/tmauthors?post=3014"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}