Los Angeles\u2019tan UCLA ara\u015ft\u0131rmac\u0131lar\u0131, \u00fcrolojide \u00e7\u0131\u011f\u0131r a\u00e7an geli\u015fmeleri American Urological Association (AUA) 2025 toplant\u0131s\u0131nda bir araya getirdi. 26-29 Nisan 2025 tarihleri aras\u0131nda Las Vegas\u2019ta d\u00fczenlenen etkinlikte, UCLA David Geffen T\u0131p Fak\u00fcltesi ve UCLA Health Jonsson Kapsaml\u0131 Kanser Merkezi\u2019nden ara\u015ft\u0131rmac\u0131lar, \u00fcrolojik alandaki yenilik\u00e7i teknolojiler ve klinik bulgular\u0131n\u0131 sunarak, te\u015fhis, cerrahi planlama ve tedavi stratejilerinde \u00f6nemli ad\u0131mlar at\u0131ld\u0131\u011f\u0131n\u0131 ortaya koydu. Toplamda k\u0131rk\u0131n \u00fczerinde oturumun yer ald\u0131\u011f\u0131 bu kapsaml\u0131 programda, kanser cerrahisinden fonksiyonel \u00fcroloji alan\u0131ndaki geli\u015fmelere kadar geni\u015f yelpazede ileri uygulamalar ele al\u0131nd\u0131.<\/p>\n
Robotik prostatektomi alan\u0131nda \u00fc\u00e7 boyutlu dijital modellemenin ameliyat ba\u015far\u0131s\u0131n\u0131 nas\u0131l etkiledi\u011fini inceleyen \u00f6nc\u00fc \u00e7al\u0131\u015fma \u00f6zellikle dikkat \u00e7ekti. Dr. Joseph Shirk ile asistan doktor Dr. Asha Ayub\u2019un liderli\u011finde y\u00fcr\u00fct\u00fclen, 2019-2022 aras\u0131nda alt\u0131 akademik merkezde ger\u00e7ekle\u015ftirilen randomize, tek k\u00f6r klinik \u00e7al\u0131\u015fmaya g\u00f6re, 3D modeller cerrahi yakla\u015f\u0131m\u0131 \u00fc\u00e7te bir oran\u0131nda de\u011fi\u015ftirdi. Multiparametrik MRI\u2019dan farkl\u0131 olarak, bu \u00fc\u00e7 boyutlu modeller t\u00fcm\u00f6r\u00fcn kritik sinir ve damar yap\u0131lar\u0131yla konumsal ili\u015fkisini daha net g\u00f6stererek, sinir koruyucu tekniklerin daha hassas uygulanmas\u0131n\u0131 sa\u011flad\u0131. Bu durum, ameliyat sonras\u0131 hem t\u00fcm\u00f6r temizli\u011finde (negatif cerrahi marjlar) hem de fonksiyonel sonu\u00e7larda (erken kontinan\u0131n geri kazan\u0131m\u0131 ve 18 aya kadar s\u00fcrd\u00fcr\u00fclen erektil fonksiyon) belirgin iyile\u015fme olarak yans\u0131d\u0131.<\/p>\n
\u00dcrolojide immunoterapinin ekonomik boyutlar\u0131na dair analizler de \u00f6nemli veriler sundu. Dr. Alexandra Drakaki ve klinik \u00f6\u011fretim g\u00f6revlisi Dr. Pratik Kanabur\u2019un \u00f6nc\u00fcl\u00fc\u011f\u00fcndeki ara\u015ft\u0131rmada, kas invaziv mesane kanserinde pembrolizumab ve nivolumab adl\u0131 iki yayg\u0131n checkpoint inhibit\u00f6r\u00fc kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131. Bu model, CheckMate 274 ve AMBASSADOR gibi b\u00fcy\u00fck klinik \u00e7al\u0131\u015fmalar\u0131n verileri kullan\u0131larak geli\u015ftirilmi\u015fti. Uzun d\u00f6nem ya\u015fam kalitesi y\u0131llar\u0131 (QALY), toksisite profilleri ve sa\u011fl\u0131k harcamalar\u0131 g\u00f6z \u00f6n\u00fcnde bulunduruldu. Her iki ilac\u0131n da sistektomi sonras\u0131 izlemeye k\u0131yasla hastal\u0131ks\u0131z sa\u011fkal\u0131m\u0131 art\u0131rmas\u0131na ra\u011fmen, pembrolizumab yakla\u015f\u0131k 50.000 dolar QALY ba\u015f\u0131na maliyet etkinlik oran\u0131yla daha uygun bulundu. Bu bulgu, etkinlik ve maliyetin birlikte de\u011ferlendirildi\u011fi ki\u015fiye \u00f6zg\u00fc tedavi planlamalar\u0131 i\u00e7in kritik bir perspektif sundu.<\/p>\n
Yapay zeka (YZ) teknolojilerinin \u00fcrolojide te\u015fhis ve prognoz alan\u0131ndaki y\u00fckselen rol\u00fc ise ba\u015fka bir dikkat \u00e7ekici \u00e7al\u0131\u015fma kapsam\u0131nda ele al\u0131nd\u0131. UCLA\u2019da y\u00fcr\u00fct\u00fclen ara\u015ft\u0131rmada, multimodal preoperatif g\u00f6r\u00fcnt\u00fcleme ve klinik parametrelerin birle\u015fimiyle prostat kanserinde seminal vezik\u00fcl invazyonunu (SVI) tahmin eden 3D kanser risk haritalar\u0131 geli\u015ftirildi. Bu haritalar, MRI\u2019da s\u0131n\u0131rl\u0131 \u00e7\u00f6z\u00fcn\u00fcrl\u00fc\u011fe ve uzman\u0131n de\u011ferlendirme farkl\u0131l\u0131klar\u0131na g\u00f6re daha y\u00fcksek do\u011fruluk g\u00f6sterdi. YZ algoritmalar\u0131, iki farkl\u0131 hasta grubunda \u00e7ok daha az SVI vakas\u0131n\u0131 ka\u00e7\u0131rarak, operasyon \u00f6ncesi evrelemede ve tedavi hedeflemede anlaml\u0131 bir iyile\u015fme potansiyeli sundu.<\/p>\n
N\u00f6rojenik alt \u00fcriner sistem disfonksiyonu (NLUTD) ve buna ba\u011fl\u0131 geli\u015fen otonomik disrefleksi (AD) gibi komplikasyonlar\u0131n y\u00f6netiminde ise yenilik\u00e7i bir giyilebilir optik cihaz devreye girdi. Dr. Lynn Stothers\u2019\u0131n ekibi, yak\u0131n k\u0131z\u0131l\u00f6tesi spektroskopi (NIRS) teknolojisi kullanan kablosuz bir sistemi tasarlad\u0131. Silikon aray\u00fcz i\u00e7ine yerle\u015ftirilmi\u015f LED yayan ve alg\u0131layan \u00e7iftler sayesinde, idrar hacmi ve detrusor oksijenasyonundaki de\u011fi\u015fimler ger\u00e7ek zamanl\u0131 \u00f6l\u00e7\u00fclebildi. 66 omurilik yaralanmal\u0131 hastada test edilen cihaz, mesane dolgunlu\u011fu ve detrusor bas\u0131nc\u0131nda de\u011fi\u015fiklikleri ay\u0131rt eden optik i\u015faretleri ortaya koydu. Bu teknolojik yenilik, ki\u015fiselle\u015ftirilmi\u015f kateter de\u011fi\u015ftirme planlar\u0131 yaparak hayat\u0131 tehdit eden AD n\u00f6betlerini \u00f6nlemeye y\u00f6nelik b\u00fcy\u00fck bir potansiyel ta\u015f\u0131yor.<\/p>\n
B\u00f6brek ta\u015f\u0131 y\u00f6netiminde ortak karar alma (shared decision-making – SDM) s\u00fcre\u00e7lerinin etkinle\u015ftirilmesine y\u00f6nelik \u00e7al\u0131\u015fmalar da UCLA\u2019n\u0131n \u00f6ncelikleri aras\u0131nda yer ald\u0131. Dr. Christopher Saigal ve Saam Kazemi\u2019nin \u00f6nc\u00fcl\u00fc\u011f\u00fcndeki ara\u015ft\u0131rmada, hasta-doktor i\u015f birli\u011fini art\u0131ran \u00e7evrimi\u00e7i karar destek arac\u0131n\u0131n klinik uygulamadaki benimsenmesi ve kullan\u0131m kalitesi \u00fc\u00e7 ayl\u0131k d\u00f6nem i\u00e7inde de\u011ferlendirildi. Ba\u015flang\u0131\u00e7ta beklenen \u2018eri\u015fim\u2019 (kullan\u0131c\u0131ya ula\u015fma oran\u0131) ve \u2018fidelite\u2019 (do\u011fru ve eksiksiz kullan\u0131m oran\u0131) hedeflerinin gerisinde kalmas\u0131, PDSA (Plan-Do-Study-Act) d\u00f6ng\u00fcleriyle kalite iyile\u015ftirme m\u00fcdahalelerini zorunlu k\u0131ld\u0131. \u00c7al\u0131\u015fma, teknolojinin kullan\u0131labilirli\u011fi ve klinisyenlerin kat\u0131l\u0131m\u0131n\u0131n dengelenmesinde \u00f6nemli engeller oldu\u011funu ve bunlar\u0131n a\u015f\u0131lmas\u0131 halinde d\u00f6n\u00fc\u015ft\u00fcr\u00fcc\u00fc hasta merkezli bak\u0131ma olanak sa\u011flanaca\u011f\u0131n\u0131 vurgulad\u0131.<\/p>\n
UCLA\u2019n\u0131n sundu\u011fu bu multidisipliner ve ileri teknoloji bazl\u0131 \u00e7al\u0131\u015fmalar toplulu\u011fu, \u00fcroloji alan\u0131nda hem onkolojik hem de fonksiyonel literat\u00fcrde paradigmalar\u0131 de\u011fi\u015ftirmeye aday. \u00dc\u00e7 boyutlu cerrahi modelleme ile hem\u00f6rens sinir hasar\u0131n\u0131n azalt\u0131lmas\u0131 sa\u011flan\u0131rken, imm\u00fcnoterapi alan\u0131ndaki maliyet-etkinlik verileri kaynaklar\u0131n s\u00fcrd\u00fcr\u00fclebilir kullan\u0131m\u0131n\u0131 destekliyor. Yapay zekan\u0131n \u00f6nceden tan\u0131 ve evrelemedeki ba\u015far\u0131s\u0131, klinik karar s\u00fcre\u00e7lerini daha isabetli ve etkili k\u0131larken, giyilebilir optik sistemler n\u00f6rojenik mesane y\u00f6netiminde ya\u015fam kalitesini art\u0131r\u0131yor. Ayr\u0131ca, dijital karar destek sistemlerindeki geli\u015fmeler, hasta-doktor diyaloglar\u0131n\u0131 g\u00fc\u00e7lendirerek sa\u011fl\u0131kta bireyselle\u015fmeyi h\u0131zland\u0131r\u0131yor.<\/p>\n
Las Vegas\u2019taki The Venetian Convention & Expo Center\u2019da ger\u00e7ekle\u015ftirilen etkinlik, Marco Polo ve Galileo salonlar\u0131 gibi \u00f6zel mekanlarda UCLA ara\u015ft\u0131rmac\u0131lar\u0131na do\u011frudan eri\u015fim imkan\u0131 sundu. Ger\u00e7ek klinik deneme verileri, karma\u015f\u0131k analitik modellemeler ve yenilik\u00e7i yapay zeka yakla\u015f\u0131m\u0131n\u0131n kayna\u015ft\u0131\u011f\u0131 sunumlar, UCLA\u2019n\u0131n ulusal ve uluslararas\u0131 \u00fcroloji alan\u0131nda \u00f6nc\u00fc konumunu peki\u015ftirdi. Bu bulgular\u0131n pratik uygulamalara ve uluslararas\u0131 protokollere yans\u0131mas\u0131, hastalar\u0131n ya\u015fam kalitesini olumlu \u015fekilde d\u00f6n\u00fc\u015ft\u00fcrme potansiyelini art\u0131r\u0131yor.<\/p>\n
Prostat kanseri cerrahisindeki paradigma kaymas\u0131, dijital \u00fc\u00e7 boyutlu modellerin kullan\u0131m\u0131yla, t\u00fcm\u00f6r anatomi ve sinir koruyucu tekniklerin optimize edilmesini m\u00fcmk\u00fcn k\u0131ld\u0131. Mesane kanserinde imm\u00fcnoterapiye ili\u015fkin detayl\u0131 maliyet etkinlik analizleri, sa\u011fl\u0131k kaynaklar\u0131n\u0131n adaletli ve ak\u0131lc\u0131 da\u011f\u0131t\u0131m\u0131 i\u00e7in kritik. Yapay zeka destekli kanser risk haritalar\u0131n\u0131n tan\u0131sal duyarl\u0131l\u0131\u011f\u0131n\u0131 art\u0131rmas\u0131, multidisipliner ekiplerin i\u015f birli\u011fini kolayla\u015ft\u0131rarak operasyon \u00f6ncesi planlamay\u0131 geli\u015ftiriyor. N\u00f6rojenik mesane fonksiyonlar\u0131n\u0131n yak\u0131ndan izlenmesi ise optik fizik ve biyomedikal m\u00fchendislik alanlar\u0131n\u0131n \u00fcrolojiye katk\u0131lar\u0131n\u0131n somut bir \u00f6rne\u011fi.<\/p>\n
Ayr\u0131ca, payla\u015f\u0131lm\u0131\u015f karar alma ara\u00e7lar\u0131n\u0131n daha geni\u015f \u00e7apta sa\u011fl\u0131k sistemine entegre edilmesi y\u00f6n\u00fcndeki \u00e7abalar, \u015feffafl\u0131k ve hastalar\u0131n tedavi s\u00fcre\u00e7lerine aktif kat\u0131l\u0131m\u0131n\u0131 vurgulayan g\u00fcn\u00fcm\u00fcz sa\u011fl\u0131k paradigmas\u0131na uyum sa\u011fl\u0131yor. UCLA\u2019n\u0131n AUA 2025\u2019teki katk\u0131lar\u0131, teknolojik geli\u015fmeler ile hasta odakl\u0131 bak\u0131m\u0131n bir araya geldi\u011fi yeni bir \u00e7a\u011f\u0131n ba\u015flang\u0131c\u0131na i\u015faret ediyor. Bu bilimsel ve teknolojik ilerlemelerin klinik prati\u011fe yay\u0131lmas\u0131, d\u00fcnya \u00e7ap\u0131nda \u00fcrolojik hastal\u0131klar\u0131n y\u00f6netiminde \u00f6nemli de\u011fi\u015fiklikler yaratacak.<\/p>\n
Sonu\u00e7 olarak, UCLA ara\u015ft\u0131rmac\u0131lar\u0131n\u0131n bu kapsaml\u0131 \u00e7al\u0131\u015fmalar\u0131, \u00fcroloji alan\u0131nda tan\u0131dan tedaviye kadar pek \u00e7ok kritik a\u015famada yeni standartlar\u0131n belirlenmesinde \u00f6nc\u00fcl\u00fck ediyor. 3D cerrahi planlama, imm\u00fcnoterapi ekonomik modelleri, yapay zek\u00e2 destekli g\u00f6r\u00fcnt\u00fc analizleri, giyilebilir mesane izleme cihazlar\u0131 ve dijital karar alma platformlar\u0131 gibi yenilikler, gelece\u011fin hasta bak\u0131m\u0131n\u0131 \u015fekillendiriyor. Bu ilerlemeler, \u00fcrolojik hastalar\u0131n ya\u015fam kalitesini art\u0131r\u0131rken, sa\u011fl\u0131k sistemlerinin verimlili\u011fini de destekleyen s\u00fcrd\u00fcr\u00fclebilir ve hasta merkezli \u00e7\u00f6z\u00fcmler sunuyor.<\/p>\n
—<\/p>\n
**Ara\u015ft\u0131rma Konusu**: Innovations in Urologic Oncology and Functional Urology, including 3D surgical modeling, immunotherapy cost-effectiveness, AI-driven cancer diagnostics, wearable bladder monitoring, and shared decision-making in kidney stone care.<\/p>\n
**Makale Ba\u015fl\u0131\u011f\u0131**: UCLA Researchers Unveil Breakthroughs in Urology at AUA 2025: From 3D Models to AI Diagnostics and Wearable Technologies<\/p>\n
**Haberin Yay\u0131n Tarihi**: April 2025<\/p>\n
**Web References**:
\nhttps:\/\/www.auanet.org\/AUA2025\/program
\nhttps:\/\/www.uclahealth.org\/providers\/christopher-saigal
\nhttps:\/\/www.uclahealth.org\/providers\/joseph-shirk
\nhttps:\/\/www.uclahealth.org\/providers\/alexandra-drakaki
\nhttps:\/\/www.uclahealth.org\/providers\/mary-ann-stothers<\/p>\n
**Anahtar Kelimeler**: Urology, Prostate Cancer, Robotic Surgery, 3D Modeling, Bladder Cancer, Checkpoint Inhibitors, AI Diagnostics, Seminal Vesicle Invasion, Neurogenic Bladder, Wearable Optical Device, Shared Decision-Making, Kidney Stones<\/p>\n","protected":false},"excerpt":{"rendered":"
Los Angeles\u2019tan UCLA ara\u015ft\u0131rmac\u0131lar\u0131, \u00fcrolojide \u00e7\u0131\u011f\u0131r a\u00e7an geli\u015fmeleri American Urological Association (AUA) 2025 toplant\u0131s\u0131nda bir araya getirdi. 26-29 Nisan 2025 tarihleri aras\u0131nda Las Vegas\u2019ta d\u00fczenlenen etkinlikte, UCLA David Geffen T\u0131p Fak\u00fcltesi ve UCLA Health Jonsson Kapsaml\u0131 Kanser Merkezi\u2019nden ara\u015ft\u0131rmac\u0131lar, \u00fcrolojik alandaki yenilik\u00e7i teknolojiler ve klinik bulgular\u0131n\u0131 sunarak, te\u015fhis, cerrahi planlama ve tedavi stratejilerinde \u00f6nemli ad\u0131mlar…<\/p>\n","protected":false},"author":1,"featured_media":3418,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_yoast_wpseo_title":"","_yoast_wpseo_metadesc":"","_yoast_wpseo_focuskw":"","rank_math_title":"","rank_math_description":"","rank_math_focus_keyword":"","_wpan_schema_json_ld":"","_wpan_ai_seo_metadata":"","_wpan_ai_seo_status":"","_wpan_ai_seo_policy":"","_wpan_ai_seo_faq_block":"","_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[28],"tags":[2099,2101,2098,2097,2100],"tmauthors":[],"class_list":{"0":"post-3417","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-kanser","8":"tag-kas-invaziv-mesane-kanseri-immunoterapi-maliyet-etkinligi","9":"tag-multiparametrik-mri-ve-sinir-koruyucu-cerrahi-teknikleri","10":"tag-robotik-prostatektomi-3d-modelleme-uygulamalari","11":"tag-ucla-uroloji-inovasyonlari","12":"tag-yapay-zeka-destekli-urolojik-teshis-ve-tedavi"},"jetpack_featured_media_url":"https:\/\/haber360.com\/wp-content\/uploads\/2025\/04\/UCLA8217dan-Prostat-Mesane-ve-Yapay-Zeka-Inovasyonlari-1745268284.jpg","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/posts\/3417","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/comments?post=3417"}],"version-history":[{"count":0,"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/posts\/3417\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/media\/3418"}],"wp:attachment":[{"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/media?parent=3417"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/categories?post=3417"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/tags?post=3417"},{"taxonomy":"tmauthors","embeddable":true,"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/tmauthors?post=3417"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}