Bilim d\u00fcnyas\u0131nda a\u015f\u0131 teknolojisi ve kanser imm\u00fcnoterapisi alanlar\u0131nda devrim niteli\u011finde bir geli\u015fme ya\u015fand\u0131. Avustralya\u2019n\u0131n \u00f6nde gelen ara\u015ft\u0131rma merkezlerinden Walter and Eliza Hall Enstit\u00fcs\u00fc (WEHI) bilim insanlar\u0131, ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin uzun vadeli haf\u0131zas\u0131n\u0131 g\u00fc\u00e7lendirmek i\u00e7in CD8+ T h\u00fccrelerinin benzersiz bir alt grubunu hedef alan yenilik\u00e7i bir y\u00f6ntem geli\u015ftirdi. Stem cell-like memory (k\u00f6k h\u00fccre benzeri haf\u0131za) CD8+ T h\u00fccreleri olarak adland\u0131r\u0131lan bu h\u00fccreler, ola\u011fan\u00fcst\u00fc kendini yenileme \u00f6zellikleri sayesinde a\u015f\u0131lar\u0131n kal\u0131c\u0131 koruma sa\u011flamas\u0131nda \u00f6nemli bir rol oynayabilecek potansiyele sahipler. Journal of Experimental Medicine dergisinde yay\u0131mlanan bu \u00e7al\u0131\u015fmada, tip I interferon sinyalinin ge\u00e7ici olarak engellenmesinin, bu kritik h\u00fccrelerin \u201ck\u00f6k h\u00fccre \u00f6zelliklerini\u201d art\u0131rd\u0131\u011f\u0131 ve b\u00f6ylece a\u015f\u0131 kaynakl\u0131 ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131n \u00e7ok daha uzun s\u00fcrelere ta\u015f\u0131nabildi\u011fi mekaniksel olarak a\u00e7\u0131kland\u0131.<\/p>\n
Geleneksel a\u015f\u0131lar genellikle vir\u00fcs veya bakteri gibi patojenlerin y\u00fczey antijenlerine kar\u015f\u0131 g\u00fc\u00e7l\u00fc antikor yan\u0131tlar\u0131 olu\u015fturmak \u00fczere tasarlanm\u0131\u015ft\u0131r. Ancak bu antikor seviyeleri zamanla d\u00fc\u015fer ve koruyucu ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131n s\u00fcrd\u00fcr\u00fclebilmesi i\u00e7in takviye dozlar gereklidir. \u00d6zellikle influenza ve SARS-CoV-2 gibi h\u0131zla mutasyona u\u011frayan vir\u00fcslerdeantijenik s\u00fcr\u00fcklenme (antigenic drift) nedeniyle antikorlar etkisiz kalmakta ve bu da ba\u011f\u0131\u015f\u0131kl\u0131k korumas\u0131n\u0131n s\u00fcresi ve kapsam\u0131n\u0131 k\u0131s\u0131tlamaktad\u0131r. Bu \u00f6nemli sorun, sadece antikor \u00fcretimini tetiklemekle kalmay\u0131p ayn\u0131 zamanda uzun \u00f6m\u00fcrl\u00fc ve geni\u015f h\u00fccresel ba\u011f\u0131\u015f\u0131kl\u0131k uyand\u0131rabilen yeni nesil a\u015f\u0131 gereklili\u011fini ortaya koyuyor. WEHI ara\u015ft\u0131rmac\u0131lar\u0131, bu ihtiyac\u0131 gidermek \u00fczere CD8+ T h\u00fccrelerinin k\u00f6k h\u00fccre benzeri haf\u0131za \u00f6zelliklerine odakland\u0131lar; bu T h\u00fccreleri h\u0131zl\u0131 \u00e7o\u011falabilme ve uzun s\u00fcre hayatta kalabilme yetenekleriyle kal\u0131c\u0131 koruma i\u00e7in ideal bir hedef haline geliyor.<\/p>\n
Stem cell-like memory CD8+ T h\u00fccreleri geleneksel efekt\u00f6r veya merkezi haf\u0131za T h\u00fccrelerinden k\u00f6k h\u00fccre benzeri \u00f6zellikleriyle ayr\u0131l\u0131r; yeniden kar\u015f\u0131la\u015f\u0131lan antijene kar\u015f\u0131 geni\u015f \u00e7apta \u00e7o\u011falabilir, uzun s\u00fcre kendini yenileyebilir ve g\u00fc\u00e7l\u00fc sitotoksik efekt\u00f6r h\u00fccrelere d\u00f6n\u00fc\u015febilirler. Bu nitelikler, viral patojenlere ve t\u00fcm\u00f6r h\u00fccrelerine kar\u015f\u0131 uzun s\u00fcreli koruyucu ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131n s\u00fcrd\u00fcr\u00fclmesinde vazge\u00e7ilmez k\u0131lar. Ancak in vivo olarak bu spesifik h\u00fccre pop\u00fclasyonunu se\u00e7ici bi\u00e7imde art\u0131rma y\u00f6ntemleri uzun s\u00fcredir eksikti. WEHI ara\u015ft\u0131rmac\u0131lar\u0131, mRNA a\u015f\u0131 teknolojisi ile imm\u00fcnomod\u00fclat\u00f6r m\u00fcdahaleleri ustaca birle\u015ftirerek bu h\u00fccre grubunun fare modellerinde ba\u015far\u0131yla \u00e7o\u011falmas\u0131n\u0131 sa\u011flad\u0131 ve artan bu h\u00fccre say\u0131s\u0131n\u0131n geli\u015fmi\u015f a\u015f\u0131 etkinli\u011fiyle yak\u0131n ili\u015fki i\u00e7inde oldu\u011funu ortaya koydu.<\/p>\n
\u00c7al\u0131\u015fman\u0131n merkezinde tip I interferon (IFN) sinyalinin a\u015f\u0131lanma d\u00f6neminde ge\u00e7ici olarak bloke edilmesi yer al\u0131yor. Tip I IFN\u2019ler antiviral savunma ve ba\u011f\u0131\u015f\u0131kl\u0131k d\u00fczenlenmesinde kritik rol oynayan sitokinlerdir; ancak s\u00fcrekli aktivasyonlar\u0131, CD8+ T h\u00fccrelerinde terminal farkl\u0131la\u015fma ve yorgunlu\u011fa yol a\u00e7arak etkili haf\u0131za olu\u015fumunu engelleyebilir. Tip I IFN yan\u0131tlar\u0131n\u0131n ge\u00e7ici olarak engellenmesiyle, stem cell-like memory T h\u00fccrelerinin farkl\u0131la\u015fmas\u0131 ve \u00e7o\u011falmas\u0131 i\u00e7in uygun bir ortam sa\u011fland\u0131. Bu ince ayarl\u0131 mod\u00fclasyon sayesinde hemen patojen temizli\u011fi ile uzun vadeli ba\u011f\u0131\u015f\u0131kl\u0131k balans\u0131 g\u00f6zetildi ve uzun \u00f6m\u00fcrl\u00fc ve geni\u015f kapsaml\u0131 ba\u011f\u0131\u015f\u0131kl\u0131k yan\u0131t\u0131 lehine bir e\u011filim geli\u015ftirildi. Bu bulgunun temel imm\u00fcnoloji alan\u0131n\u0131n \u00f6tesinde, ak\u0131lc\u0131 a\u015f\u0131 tasar\u0131m\u0131na g\u00fc\u00e7l\u00fc bir mekaniksel temel sa\u011flad\u0131\u011f\u0131 a\u00e7\u0131k\u00e7a ortaya \u00e7\u0131kt\u0131.<\/p>\n
mRNA a\u015f\u0131 platformlar\u0131n\u0131n yenilik\u00e7i kullan\u0131m\u0131, bu ba\u011flamda dikkat \u00e7ekicidir. mRNA a\u015f\u0131lar\u0131 h\u0131zl\u0131 geli\u015ftirme s\u00fcre\u00e7leri, kesin antijen kodlama yetenekleri ve g\u00fcvenlik profilleri nedeniyle ba\u011f\u0131\u015f\u0131klama stratejilerinde devrim yaratm\u0131\u015ft\u0131r. WEHI ekibi, bu \u00f6zellikleri kullanarak mRNA a\u015f\u0131lar\u0131n\u0131 tip I IFN yolak inhibit\u00f6rleriyle birle\u015ftirdi ve stem cell-like memory CD8+ T h\u00fccrelerinin g\u00fc\u00e7l\u00fc art\u0131\u015f\u0131n\u0131 tetikledi. Bu \u00e7ift y\u00f6nl\u00fc yakla\u015f\u0131m, mRNA teknolojisinin esnekli\u011fini kullan\u0131rken, imm\u00fcn sinyal yolaklar\u0131n\u0131 gezegen olarak manip\u00fcle ederek T h\u00fccre yan\u0131t\u0131n\u0131n kalitesini ve uzun \u00f6m\u00fcrl\u00fcl\u00fc\u011f\u00fcn\u00fc art\u0131rmada e\u015fsiz bir sinerji sa\u011flad\u0131. B\u00f6ylece, a\u015f\u0131n\u0131n yaln\u0131zca antijen \u00f6zelli\u011fine de\u011fil, ayn\u0131 zamanda ba\u011f\u0131\u015f\u0131kl\u0131k ortam\u0131n\u0131n \u00f6zel ko\u015fulland\u0131r\u0131lmas\u0131na g\u00f6re \u015fekillendirilebilece\u011fi yeni bir paradigma kap\u0131s\u0131 araland\u0131.<\/p>\n
Ara\u015ft\u0131rma sadece bula\u015f\u0131c\u0131 hastal\u0131klar i\u00e7in de\u011fil, kanser imm\u00fcnoterapisi alan\u0131nda da b\u00fcy\u00fck anlam ta\u015f\u0131yor. CD8+ T h\u00fccreleri, d\u00f6n\u00fc\u015ft\u00fcr\u00fclm\u00fc\u015f (transformed) h\u00fccreleri do\u011frudan yok etmede temel sitotoksik roller \u00fcstlenirler. Bu h\u00fccrelerin k\u00f6k h\u00fccre \u00f6zellikleri ile dayan\u0131kl\u0131l\u0131\u011f\u0131n\u0131n art\u0131r\u0131lmas\u0131, T h\u00fccre yorgunlu\u011fu ve t\u00fcm\u00f6r\u00fcn ba\u011f\u0131\u015f\u0131kl\u0131ktan ka\u00e7ma problemlerinin \u00fcstesinden gelinmesine olanak tan\u0131yabilir. WEHI ara\u015ft\u0131rmac\u0131lar\u0131, k\u00f6k h\u00fccre benzeri haf\u0131za CD8+ T h\u00fccrelerini g\u00fc\u00e7lendiren mRNA a\u015f\u0131 yakla\u015f\u0131m\u0131n\u0131n mevcut kanser tedavileriyle birlikte g\u00fc\u00e7l\u00fc bir tamamlay\u0131c\u0131 olaca\u011f\u0131n\u0131 ve ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccresi infiltrasyonu az olan \u201cso\u011fuk\u201d t\u00fcm\u00f6rlerin ba\u011f\u0131\u015f\u0131kl\u0131k taraf\u0131ndan hedeflenebilen \u201cs\u0131cak\u201d t\u00fcm\u00f6rlere d\u00f6n\u00fc\u015ft\u00fcr\u00fclmesini sa\u011flayabilece\u011fini \u00f6ng\u00f6r\u00fcyor. Bu yakla\u015f\u0131m, ki\u015fiselle\u015ftirilmi\u015f kanser a\u015f\u0131lar\u0131na odaklanan g\u00fcncel terapi stratejileriyle uyumlu olup kal\u0131c\u0131 sitotoksik T h\u00fccre yan\u0131tlar\u0131n\u0131 tetiklemeyi hedeflemektedir.<\/p>\n
WEHI Ba\u011f\u0131\u015f\u0131kl\u0131k B\u00f6l\u00fcm\u00fc Ba\u015fkan\u0131 ve \u00e7al\u0131\u015fman\u0131n ba\u015fyazar\u0131 Do\u00e7ent Doktor Joanna Groom, bu bulgular\u0131n d\u00f6n\u00fc\u015f\u00fcmc\u00fc potansiyeline vurgu yapt\u0131. Groom, bu stem cell-like haf\u0131za T h\u00fccrelerinin hem ba\u011f\u0131\u015f\u0131kl\u0131k dayan\u0131kl\u0131l\u0131\u011f\u0131 hem de geni\u015f koruma kapsam\u0131 a\u00e7\u0131s\u0131ndan a\u015f\u0131lama alan\u0131ndaki iki temel soruna yan\u0131t verdi\u011fini belirtti. \u201cUzun zamand\u0131r bu h\u00fccrelerin kal\u0131c\u0131 ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131n temelini olu\u015fturdu\u011fundan \u015f\u00fcpheleniyorduk; ancak bu \u00e7al\u0131\u015fma, ilk defa bu h\u00fccrelerin faydas\u0131n\u0131 somut olarak kan\u0131tlamakla kalm\u0131yor, onlar\u0131 a\u015f\u0131lama yoluyla nas\u0131l g\u00fc\u00e7lendirebilece\u011fimizi g\u00f6steriyor,\u201d dedi. Groom\u2019un a\u00e7\u0131klamalar\u0131, a\u015f\u0131 \u00e7al\u0131\u015fmalar\u0131n\u0131 ge\u00e7ici antikor tepkilerinden kal\u0131c\u0131 h\u00fccresel imm\u00fcniteye kayd\u0131ran bu geli\u015fmenin b\u00fcy\u00fckl\u00fc\u011f\u00fcn\u00fc bir kez daha ortaya koyuyor.<\/p>\n
Ara\u015ft\u0131rma ekibi ayr\u0131ca platformun esnekli\u011fine de dikkat \u00e7ekti. mRNA a\u015f\u0131lar\u0131n\u0131n yeni viral varyant veya t\u00fcm\u00f6r neoantijenleri kodlamak \u00fczere h\u0131zla yeniden tasarlanabilme \u00f6zelli\u011fi, stem cell-like haf\u0131za CD8+ T h\u00fccrelerini g\u00fc\u00e7lendirme stratejisiyle birle\u015fti\u011finde; yeni ortaya \u00e7\u0131kan bula\u015f\u0131c\u0131 tehditlere ve de\u011fi\u015fen kanser profillerine h\u0131zla yan\u0131t verebilen \u00e7ok y\u00f6nl\u00fc, h\u0131zl\u0131 hareket eden bir sistem yarat\u0131yor. Bu h\u0131zl\u0131 uyum kabiliyeti, pandemi d\u00f6nemlerinde k\u00fcresel a\u015f\u0131 da\u011f\u0131t\u0131m\u0131n\u0131 kolayla\u015ft\u0131r\u0131rken, ki\u015fiselle\u015ftirilmi\u015f imm\u00fcnoterapi rejimlerinin t\u00fcm\u00f6r antijen profiline g\u00f6re \u015fekillendirilmesini destekleyerek klinik uygulama alan\u0131n\u0131 geni\u015fletebilir.<\/p>\n
Fare modelleri \u00fczerinde ger\u00e7ekle\u015ftirilen deneylerde, ge\u00e7ici tip I IFN engellemesi ve mRNA a\u015f\u0131s\u0131n\u0131n birle\u015ftirildi\u011fi a\u015f\u0131 rejimiyle, stem cell-like haf\u0131za CD8+ T h\u00fccrelerinin belirgin \u015fekilde artt\u0131\u011f\u0131 g\u00f6zlendi. Bu art\u0131\u015f, enfeksiyonlar\u0131n ve t\u00fcm\u00f6r\u00fcn kontrol\u00fcnde \u00fcst d\u00fczey ba\u011f\u0131\u015f\u0131kl\u0131k korumas\u0131 ile g\u00fc\u00e7l\u00fc bir korelasyon g\u00f6sterdi. Bu \u00f6nc\u00fc sonu\u00e7lar, yakla\u015f\u0131m\u0131n insan klinik deneylerine ge\u00e7i\u015fi i\u00e7in sa\u011flam bir temel olarak de\u011ferlendiriliyor. Ba\u015far\u0131yla uygulanmas\u0131 halinde, bu strateji tekrarlayan takviye a\u015f\u0131 ihtiyac\u0131n\u0131 azaltabilir ya da tamamen ortadan kald\u0131rabilir ve tek bir a\u015f\u0131lamadan y\u0131llar, hatta on y\u0131llar s\u00fcren ba\u011f\u0131\u015f\u0131kl\u0131k sa\u011flayabilir.<\/p>\n
\u00c7al\u0131\u015fman\u0131n birinci yazar\u0131 olan doktora \u00f6\u011frencisi Benjamin Broomfield, bu sistemin sadece bula\u015f\u0131c\u0131 hastal\u0131klar de\u011fil, kanser tedavilerinde de uygulama potansiyeline vurgu yapt\u0131. \u201cLaboratuvar\u0131m\u0131z\u0131n bir sonraki hedefi, bu a\u015f\u0131 platformunu kanser tedavisine uygulamak. Stem cell-like haf\u0131za T h\u00fccrelerini g\u00fc\u00e7lendirmek, kal\u0131c\u0131 anti-t\u00fcm\u00f6r ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131n\u0131 besleyerek hasta sonu\u00e7lar\u0131n\u0131 temelinden iyile\u015ftirebilir,\u201d dedi. Bu iyimserlik, ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin \u00f6z\u00fcn\u00fc kullanarak kanserin tedavisinde devrim yarat\u0131lmas\u0131n\u0131 hedefleyen k\u00fcresel bir hareketin par\u00e7as\u0131 olarak de\u011ferlendiriliyor.<\/p>\n
\u201cTransient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection\u201d ba\u015fl\u0131kl\u0131 bu \u00e7al\u0131\u015fma, temel imm\u00fcnoloji, ileri molek\u00fcler teknoloji ve translasyonel biyomedikal ara\u015ft\u0131rman\u0131n g\u00fc\u00e7l\u00fc bir birle\u015fimini temsil ediyor. D\u00fcnya olarak viral pandemiler ve diren\u00e7li kanserlerle m\u00fccadele etmeye devam ederken, WEHI ekibinin yakla\u015f\u0131m\u0131, a\u015f\u0131lar\u0131n yaln\u0131zca anl\u0131k koruma de\u011fil, ayn\u0131 zamanda \u00f6m\u00fcr boyu s\u00fcren ba\u011f\u0131\u015f\u0131kl\u0131k direnci sunaca\u011f\u0131 bir gelece\u011fi m\u00fcjdeliyor. Ara\u015ft\u0131rman\u0131n t\u00fcm detaylar\u0131na Journal of Experimental Medicine \u00fczerinden ula\u015f\u0131labilir.<\/p>\n
Ara\u015ft\u0131rma Konusu<\/strong>: H\u00fccreler Anahtar Kelimeler<\/strong>: A\u015f\u0131 ara\u015ft\u0131rmalar\u0131, T lenfositleri, antikor yan\u0131t\u0131 s\u0131n\u0131rlamalar\u0131, takviye doz gereklili\u011fi, kanser imm\u00fcnoterapisi geli\u015fmeleri, kal\u0131c\u0131 koruma, enfeksiyonlara kar\u015f\u0131 gelecek a\u015f\u0131 teknolojisi, ba\u011f\u0131\u015f\u0131kl\u0131k sistemi uzun vadeli haf\u0131zas\u0131, influenza, SARS-CoV-2 zorluklar\u0131, yenilik\u00e7i a\u015f\u0131 stratejileri, yeni nesil a\u015f\u0131 geli\u015ftirme, stem cell-like memory CD8 T h\u00fccreleri, tip I interferon sinyal inhibisyonu, a\u015f\u0131 kaynakl\u0131 ba\u011f\u0131\u015f\u0131kl\u0131k art\u0131r\u0131m\u0131<\/p>\n","protected":false},"excerpt":{"rendered":" Bilim d\u00fcnyas\u0131nda a\u015f\u0131 teknolojisi ve kanser imm\u00fcnoterapisi alanlar\u0131nda devrim niteli\u011finde bir geli\u015fme ya\u015fand\u0131. Avustralya\u2019n\u0131n \u00f6nde gelen ara\u015ft\u0131rma merkezlerinden Walter and Eliza Hall Enstit\u00fcs\u00fc (WEHI) bilim insanlar\u0131, ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin uzun vadeli haf\u0131zas\u0131n\u0131 g\u00fc\u00e7lendirmek i\u00e7in CD8+ T h\u00fccrelerinin benzersiz bir alt grubunu hedef alan yenilik\u00e7i bir y\u00f6ntem geli\u015ftirdi. Stem cell-like memory (k\u00f6k h\u00fccre benzeri haf\u0131za) CD8+ T…<\/p>\n","protected":false},"author":1,"featured_media":5068,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_yoast_wpseo_title":"","_yoast_wpseo_metadesc":"","_yoast_wpseo_focuskw":"","rank_math_title":"","rank_math_description":"","rank_math_focus_keyword":"","_wpan_schema_json_ld":"","_wpan_ai_seo_metadata":"","_wpan_ai_seo_status":"","_wpan_ai_seo_policy":"","_wpan_ai_seo_faq_block":"","_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[28],"tags":[6078,6075,6077,6074,6076],"tmauthors":[],"class_list":{"0":"post-5067","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-kanser","8":"tag-antigenik-suruklenmeye-karsi-hucresel-bagisiklik-stratejileri","9":"tag-cd8-t-hucrelerinin-kok-hucre-benzeri-hafizasi","10":"tag-immunoterapi-ve-asi-teknolojisi-gelismeleri","11":"tag-kalici-bagisiklik-saglayan-yeni-nesil-asilar","12":"tag-viral-enfeksiyonlarda-uzun-sureli-bagisiklik"},"jetpack_featured_media_url":"https:\/\/haber360.com\/wp-content\/uploads\/2025\/05\/Gelecegin-Asilari-Kalici-Bagisiklik-Saglama-Yontemleri-1746650680.jpg","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/posts\/5067","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/comments?post=5067"}],"version-history":[{"count":0,"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/posts\/5067\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/media\/5068"}],"wp:attachment":[{"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/media?parent=5067"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/categories?post=5067"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/tags?post=5067"},{"taxonomy":"tmauthors","embeddable":true,"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/tmauthors?post=5067"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nMakale Ba\u015fl\u0131\u011f\u0131<\/strong>: Transient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection
\nHaberin Yay\u0131n Tarihi<\/strong>: 10-Mar-2025
\nWeb References<\/strong>: DOI: 10.1084\/jem.20241148
\nResim Credits<\/strong>: WEHI <\/p>\n