\u0130spanya Ulusal Kanser Ara\u015ft\u0131rma Merkezi (CNIO) ara\u015ft\u0131rmac\u0131lar\u0131n\u0131n yapt\u0131\u011f\u0131 \u00e7\u0131\u011f\u0131r a\u00e7an bir \u00e7al\u0131\u015fma, kolorektal kanserin ba\u015flamas\u0131nda rol oynayan daha \u00f6nce tan\u0131mlanmam\u0131\u015f molek\u00fcler bir mekanizmay\u0131 ortaya koydu. Ara\u015ft\u0131rma, “genomun koruyucusu” olarak adland\u0131r\u0131lan t\u00fcm\u00f6r bask\u0131lay\u0131c\u0131 protein p53\u2019\u00fcn genetik kay\u0131p veya mutasyonlar\u0131ndan ziyade, aktif olarak y\u0131k\u0131m\u0131n\u0131n hastal\u0131\u011f\u0131n erken evrelerinde kolorektal kanser olu\u015fumunu tetikledi\u011fini g\u00f6steriyor. Bu bulgu, kolorektal kanserin ba\u015flang\u0131c\u0131 ve ilerleyi\u015fi hakk\u0131nda bug\u00fcne kadarki anlay\u0131\u015f\u0131m\u0131z\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde de\u011fi\u015ftirme potansiyeline sahip bulunuyor.<\/p>\n
Kolorektal kanser, d\u00fcnya genelinde en s\u0131k te\u015fhis edilen \u00fc\u00e7\u00fcnc\u00fc kanser t\u00fcr\u00fc olup, \u00e7evresel ve ya\u015fam tarz\u0131yla ili\u015fkili fakt\u00f6rler hastal\u0131k geli\u015fiminde b\u00fcy\u00fck rol oynamaktad\u0131r. Obesite, sigara, a\u015f\u0131r\u0131 alkol t\u00fcketimi, yanl\u0131\u015f diyet ve hareketsizlik gibi etkenler, kanser riskinin artmas\u0131na neden olmaktad\u0131r. Hastal\u0131k \u00e7o\u011funlukla adenomat\u00f6z polipler olarak bilinen ve potansiyel olarak malignle\u015febilen iyi huylu lezyonlardan ba\u015flar. CNIO\u2019nun yapt\u0131\u011f\u0131 yeni \u00e7al\u0131\u015fma, bu poliplerin hen\u00fcz erken safhada iken molek\u00fcler d\u00fczeyde ger\u00e7ekle\u015fen de\u011fi\u015fikliklerin t\u00fcm\u00f6r olu\u015fumunu nas\u0131l \u015fekillendirdi\u011fini detayland\u0131r\u0131yor.<\/p>\n
Dr. Nabil Djouder y\u00f6netimindeki ara\u015ft\u0131rma ekibi, kolorektal kanserin molek\u00fcler evrimini \u00e7\u00f6z\u00fcmlemek i\u00e7in geli\u015fmi\u015f hayvan modelleri kulland\u0131. Modellerde, adenoma geli\u015fimi s\u0131ras\u0131nda p53 protein y\u0131k\u0131m\u0131n\u0131n erken ve belirgin oldu\u011funu saptad\u0131lar. Daha \u00f6nce p53\u2019\u00fcn g\u00f6revi; DNA hasar\u0131 ve onkojenik stres durumlar\u0131nda h\u00fccre d\u00f6ng\u00fcs\u00fcn\u00fc durdurmak veya apoptozu tetiklemek \u015feklindeydi. Ancak yeni bulgular, genetik kay\u0131p olmadan protein seviyesindeki azal\u0131\u015f\u0131n dahi h\u00fccre proliferasyonunu kontrols\u00fcz hale getirip genomik karars\u0131zl\u0131\u011fa yol a\u00e7t\u0131\u011f\u0131n\u0131, b\u00f6ylece t\u00fcm\u00f6r olu\u015fumunu ba\u015flatt\u0131\u011f\u0131n\u0131 g\u00f6sterdi.<\/p>\n
\u00c7al\u0131\u015fman\u0131n en dikkat \u00e7ekici y\u00f6nlerinden biri, p53 stabilitesini reg\u00fcle eden yeni bir molek\u00fcler eksenin tan\u0131mlanmas\u0131 oldu. URI adl\u0131 proteinin, \u00f6zellikle hepatosell\u00fcler karsinom gibi ba\u015fka kanser t\u00fcrlerinde etkisi bilinmekle birlikte, kolorektal kanserle ili\u015fkisi daha \u00f6nce ara\u015ft\u0131r\u0131lmam\u0131\u015ft\u0131. CNIO ara\u015ft\u0131rmac\u0131lar\u0131, URI ekspresyonunun artmas\u0131n\u0131n spesifik olarak p53 proteinini hedef alarak y\u0131k\u0131m\u0131n\u0131 h\u0131zland\u0131rd\u0131\u011f\u0131n\u0131 belirledi. B\u00f6ylece p53\u2019\u00fcn t\u00fcm\u00f6r bask\u0131lay\u0131c\u0131 fonksiyonlar\u0131 ortadan kalk\u0131yor ve kanser olu\u015fumu kolayla\u015f\u0131yor.<\/p>\n
Ek olarak, onkogen MYC\u2019nin URI reg\u00fclasyonundaki rol\u00fc ortaya \u00e7\u0131kar\u0131ld\u0131. MYC, h\u00fccre \u00e7o\u011falmas\u0131n\u0131 ve t\u00fcm\u00f6r geli\u015fimini tetikleyen g\u00fc\u00e7l\u00fc bir fakt\u00f6r olarak biliniyor. Bu ara\u015ft\u0131rmaya g\u00f6re, MYC URI ekspresyonunu aktive ederek p53\u2019\u00fcn y\u0131k\u0131m\u0131n\u0131 dolayl\u0131 yoldan sa\u011fl\u0131yor<\/p>\n","protected":false},"excerpt":{"rendered":"
\u0130spanya Ulusal Kanser Ara\u015ft\u0131rma Merkezi (CNIO) ara\u015ft\u0131rmac\u0131lar\u0131n\u0131n yapt\u0131\u011f\u0131 \u00e7\u0131\u011f\u0131r a\u00e7an bir \u00e7al\u0131\u015fma, kolorektal kanserin ba\u015flamas\u0131nda rol oynayan daha \u00f6nce tan\u0131mlanmam\u0131\u015f molek\u00fcler bir mekanizmay\u0131 ortaya koydu. Ara\u015ft\u0131rma, “genomun koruyucusu” olarak adland\u0131r\u0131lan t\u00fcm\u00f6r bask\u0131lay\u0131c\u0131 protein p53\u2019\u00fcn genetik kay\u0131p veya mutasyonlar\u0131ndan ziyade, aktif olarak y\u0131k\u0131m\u0131n\u0131n hastal\u0131\u011f\u0131n erken evrelerinde kolorektal kanser olu\u015fumunu tetikledi\u011fini g\u00f6steriyor. Bu bulgu, kolorektal kanserin ba\u015flang\u0131c\u0131…<\/p>\n","protected":false},"author":1,"featured_media":5218,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_yoast_wpseo_title":"","_yoast_wpseo_metadesc":"","_yoast_wpseo_focuskw":"","rank_math_title":"","rank_math_description":"","rank_math_focus_keyword":"","_wpan_schema_json_ld":"","_wpan_ai_seo_metadata":"","_wpan_ai_seo_status":"","_wpan_ai_seo_policy":"","_wpan_ai_seo_faq_block":"","_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[28],"tags":[6440,6436,6439,6437,6438],"tmauthors":[],"class_list":{"0":"post-5217","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-kanser","8":"tag-kolorektal-kanser-erken-evre-molekuler-degisiklikleri","9":"tag-kolorektal-kanser-molekuler-mekanizmalari","10":"tag-myc-onkogenin-kolorektal-kanserde-rolu","11":"tag-p53-protein-yikimi-ve-kolorektal-kanser","12":"tag-uri-proteini-ve-p53-regulasyonu"},"jetpack_featured_media_url":"https:\/\/haber360.com\/wp-content\/uploads\/2025\/05\/Kolon-Kanserinde-Molekuler-Tetkikci-Kesfi-1746724447.jpg","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/posts\/5217","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/comments?post=5217"}],"version-history":[{"count":0,"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/posts\/5217\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/media\/5218"}],"wp:attachment":[{"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/media?parent=5217"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/categories?post=5217"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/tags?post=5217"},{"taxonomy":"tmauthors","embeddable":true,"href":"https:\/\/haber360.com\/index.php\/wp-json\/wp\/v2\/tmauthors?post=5217"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}